Targeting FOXK2 in triple-negative breast cancer: Role of the P53/MCAS1/miR-211–5p regulatory axis

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Analysis reveals the p53/mcas1/mir-211-5p/foxk2 axis influences aggressiveness in tnbc.

Foxk2 was significantly upregulated in TNBC tissues, enhancing cell proliferation and invasion.
Clinical correlation showed a link between Foxk2 expression and tumor size and lymphatic involvement.
P53 interacts directly with the mcasa1 promoter, leading to decreased transcription of mcasa1.
Silencing Foxk2 reduced aggressive traits in TNBC cells, suggesting its potential as a therapeutic target.

Wu et al. (2025) studied this question.

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