September 5, 2025Terapevticheskii arkhivOpen Access

Features of the phenotypic manifestations of GERD in its comorbidity with obesity

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Discussion

Observational analysis of GERD manifestations in patients with obesity indicates pH variability, suggesting tailored treatment strategies.

Patients with obesity exhibit prolonged duration of chemical clearance in GERD compared to those with normal weight.
Increased frequency of mixed gastric and duodenal reflux was observed alongside rising body mass index.
Clinical assessments reveal that esophageal pH-impedancometry offers valuable insights into disease severity and treatment options.
The findings highlight the importance of individualized therapeutic approaches based on phenotypic characteristics.

Маев et al. (2025) studied this question.

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Observational analysis of GERD manifestations in patients with obesity indicates pH variability, suggesting tailored treatment strategies.