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September 5, 2025JAMA Network OpenOpen Access

Low Measles Seropositivity in Vaccinated Children

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Authors

HQHuy Quang QuachSJSara Pace JonesIJIype Joseph

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Overview

Cross-sectional study assessed measles seropositivity in vaccinated children, highlighting ongoing breakthrough infections in India.

Key Points

  • Significant measles immunity gaps exist despite high vaccine coverage, posing challenges to elimination efforts.
  • About 90.8% of children showed positive measles-specific IgG, indicating substantial immunity; however, gaps remain.
  • This cross-sectional study involved 684 vaccinated children and their mothers, analyzing antibody responses to measles.
  • Findings indicate a need to strengthen immunization programs to address suboptimal immune responses to measles vaccination.

Cite This Study

Quach et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d647770c2https://doi.org/10.1001/jamanetworkopen.2025.29409
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A study on measles immunity among pregnant women in Sri Lanka, conducted concurrently with the country’s efforts to eliminate the disease2025
  2. 2Analysis of Measles Outbreaks reported to Integrated Disease Surveillance Programme (IDSP), India, 2019-20232025
  3. 3Assessment of immunity to the measles virus through the detection of IgG antibodies2025
  4. 4Measles Vaccination Coverage After a Postelimination Outbreak2025
  5. 5A systematic review and modelling insights of factors impacting measles vaccine effectiveness, efficacy and immunogenicity2025