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September 5, 2025DiagnosticsOpen Access

Neutrophil to Lymphocyte Ratio a Prognostic Tool in Endometrial Cancer Among Classical Prognostic Factors

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Authors

AKAlexandra Timea Kirsch-ManguAȚAlexandru ȚîpcuVGVlad Alexandru Gâta

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Overview

Retrospective cohort study evaluates NLR’s impact on overall survival in endometrial cancer patients, suggesting new personalized treatment strategies.

Key Points

  • Patients with neutrophil-to-lymphocyte ratio ≥ 2.27 had significantly reduced median overall survival at 72.3 months compared to 92.8 months for those with lower ratios.
  • A preoperative neutrophil-to-lymphocyte ratio cutoff of 2.27 indicates independent predictive value regarding overall survival outcomes.
  • Analysis conducted in a cohort of 398 patients with histologically confirmed endometrial adenocarcinoma, examining survival outcomes with various treatment modalities.
  • Integration of NLR into preoperative assessments may improve risk stratification, although validation is needed given the retrospective design.

Cite This Study

Kirsch-Mangu et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d64776f2ehttps://doi.org/10.3390/diagnostics15172172
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Also Consider

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  4. 4Validation of neutrophil-to-lymphocyte ratio for prognosis and treatment selection in muscle-invasive bladder cancer: A single-institutional longitudinal study2025
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