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August 21, 2025CureusOpen Access

Optimal Cutoff for the Neutrophil-to-Lymphocyte Ratio as a Tool for Pre-chemotherapy Prognosis Stratification of Breast Cancer Patients

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Authors

AZArmita ZandiAQAlyssa QianMOMaha Othman

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Overview

Longitudinal analysis identifies optimal NLR cutoff in breast cancer patients undergoing chemotherapy, implying better prognostic stratification.

Key Points

  • The optimal cutoff for the neutrophil-to-lymphocyte ratio is determined at 3.0, predicting faster progression of advanced-stage breast cancer.
  • Diagnostic metrics show significant variations across NLR cutoffs, with p < 0.001 indicating substantial differences.
  • Longitudinal quantitative analysis was utilized to assess various NLR thresholds and their effectiveness in prognosis.
  • Findings support personalized treatment approaches by aiding in risk stratification for breast cancer patients prior to chemotherapy.

Cite This Study

Zandi et al. (2025) studied this question.

synapsesocial.com/papers/68af76bf7567bf4f94fefea8https://doi.org/10.7759/cureus.90705
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