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September 5, 2025Journal of Biomedical Research & Environmental Sciences

Role of Cyclooxygenase-2 Inhibitors in Animal Models of Epilepsy: A Systematic Review

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Authors

SSSomia SMFMuhammad FN

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Overview

Systematic review reveals COX-2 inhibitors reduce seizures and provide neuroprotection in animal models, highlighting research gaps.

Key Points

  • COX-2 inhibitors decrease seizures and provide neuroprotection in various animal models of epilepsy.
  • Efficacy of COX-2 inhibitors shows a significant range, affecting seizure control and neuroprotection.
  • Considerable gaps exist in standardizing dosage and evaluating long-term effects of COX-2 inhibitors.
  • Recommendations for future studies highlight the need for optimized treatment protocols and further exploration of mechanisms.

Cite This Study

S et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d64776e91https://doi.org/10.37871/jbres2156
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  1. 1Anti-Inflammatory Mechanisms of Selective Cox-2 Inhibitors: A Preclinical Analysis2025
  2. 2Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials2023
  3. 3Recent Advances in the Therapeutic Prospective of Heterocyclic Derivatives as COX-2 Inhibitors (2019-Present)2025
  4. 4Mechanisms Involved in the Adverse Cardiovascular Effects of Selective Cyclooxygenase-2 Inhibitors2025
  5. 5A comprehensive review of drug-resistant epilepsy and animal models: Existing and emerging therapies and future research directions2025