September 5, 2025Open Access

Optimizing Gold Nanoparticles for Combination Therapy: Development of Hydrophobic Nanomedical Devices with Gemcitabine and Ascorbyl Palmitate

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The Au-GEM-AsP-COV formulation exhibited superior cytotoxicity (IC50 of 0.44 µg/mL) compared to free gemcitabine.
Gold nanoparticles were modified through emulsification, achieving optimal encapsulation efficiencies of up to 89.5%.
The study developed two formulations with different nano sizes to enhance drug stability and targeting via the EPR effect.
The findings indicate that incorporating ascorbyl palmitate can significantly enhance the efficacy of gemcitabine in cancer therapy.

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This research demonstrates enhanced cytotoxicity in a breast cancer cell line using gold nanoparticles, indicating improved therapeutic efficacy.

Rezaei et al. (2025) studied this question.

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This research demonstrates enhanced cytotoxicity in a breast cancer cell line using gold nanoparticles, indicating improved therapeutic efficacy.