August 16, 2025

Intrinsic and extrinsic factors affecting the evolution of virulence in the HIV-associated opportunistic human fungal pathogen

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Isolates from HIV-uninfected individuals show significantly enhanced virulence traits compared to those from HIV-infected patients.
Sequence type 5 was predominant in clinical isolates, although HIV-uninfected isolates displayed greater genotypic diversity.
Whole-genome sequencing indicated that genes like CDA3 and GPD1 are linked to virulence evolution in C. neoformans.
Results underscore the importance of host immunity and genetic factors in shaping the virulence of this pathogen.

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Analysis reveals how genetic and environmental factors affect C. neoformans virulence in HIV-infected and uninfected individuals.

Wang et al. (2025) studied this question.

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