September 10, 2025Cell ReportsOpen Access

Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts

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Genome evolution of Cryptococcus neoformans during chronic infection involves large-scale restructuring and increased heterogeneity.
Distinct sublineages of Cryptococcus neoformans emerge within the same host tissues, indicating diversifying selection.
Phenotypic changes include variations in virulence traits and antifungal resistance among fungal populations.
Understanding genomic adaptation during chronic infections can improve treatment strategies for opportunistic pathogens.

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Implication

Case studies reveal significant genomic changes and phenotypic diversity within Cryptococcus neoformans during chronic infections, suggesting complex evolution.

Cite This Study

Montoya et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479f9b0 https://doi.org/10.1016/j.celrep.2025.116103

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Implication

Case studies reveal significant genomic changes and phenotypic diversity within Cryptococcus neoformans during chronic infections, suggesting complex evolution.

Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts

Key Points

Discussion

Implication

Cite This Study

Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts

Key Points

Discussion

Implication

Cite This Study

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