The m6A methyltransferase METTL14 promotes oncogenic Kras induced juvenile myelomonocytic leukemia through dysregulating autophagy

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Research shows knockout of METTL14 inhibits leukemia progression in Kras mutation models, suggesting autophagy's role in JMML.

Knockout of METTL14 significantly reduces leukemia progression in models with Kras mutation, highlighting its oncogenic contribution.
Autophagy-related genes were downregulated with METTL14 knockout, resulting in decreased HSPC hyperproliferation and disease severity.
A combined treatment with an m6A inhibitor and a MEK inhibitor suppressed juvenile myelomonocytic leukemia growth.
These findings underline the significance of m6A modification in the development of juvenile myelomonocytic leukemia.

Zhang et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark