August 19, 2025BMC MedicineOpen Access

Exploring the effect of pre-clinical Alzheimer’s disease on blood pressure using Mendelian randomisation and parental dementia as an instrumental variable in UK Biobank

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Pre-clinical Alzheimer's disease increases systolic blood pressure, indicating a possible link between the two conditions.
Higher parental dementia scores showed a 0.12 mmHg increase in systolic blood pressure per standard deviation, while genetic scores showed a 0.07 mmHg increase.
Using Mendelian randomisation, the study analyzed 501,420 adults while excluding those with existing clinical Alzheimer's disease.
Understanding blood pressure changes across Alzheimer's stages may enable improved management and therapy targeting.

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Analysis shows pre-clinical Alzheimer's increases systolic blood pressure in adults, implying a need for targeted interventions.

Palmer et al. (2025) studied this question.

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