August 14, 2025The OncologistOpen Access

The Global and Regional Burden of Early-Onset Gastric Cancer (15–49y, 1990–2021): Incidence and Mortality with Projections to 2030

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Analysis shows declining rates of early-onset gastric cancer incidence and mortality, indicating demographic impact in different regions.

Early-onset gastric cancer incidence and mortality are projected to decline by 2030, though total cases may rise due to population growth.
In 2021, early-onset gastric cancer accounted for 125,120 new cases and 78,871 deaths, particularly affecting East Asia and high-middle-income regions.
Using Global Burden of Disease data, a Bayesian age-period-cohort model examined trends from 1990-2021, revealing significant epidemiological drivers.
Disparities in early-onset gastric cancer exist across gender, geography, and development, highlighting the need for targeted interventions.

Jiang et al. (2025) studied this question.

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