September 10, 2025Annals of MedicineOpen Access

Epidemiological trends of early-onset gastrointestinal cancers from 1990 to 2021 and predictions for 2036: analysis from the global burden of disease study 2021

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Analysis reveals rising incidence and mortality of early-onset gastrointestinal cancers, suggesting urgent healthcare strategies are necessary.

Early-onset gastrointestinal cancers constitute a growing global health issue, affecting individuals 15-49 years old.
In 2021, there were about 499,800 new cases globally, with colorectal cancer showing a slight increase in incidence.
Joinpoint regression was used to analyze trends from 1990-2021, with Bayesian models projecting future rates until 2036.
Notable disparities in cancer burden exist across regions, genders, and socio-demographic indices, highlighting a need for targeted interventions.

Gong et al. (2025) studied this question.

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Analysis reveals rising incidence and mortality of early-onset gastrointestinal cancers, suggesting urgent healthcare strategies are necessary.