Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 12, 2025Cerebral CortexOpen Access

Neurophysiological correlates of modifiable dementia risk factors in cognitively unimpaired older adults

View Full Paper
Ask AI
Bookmark
Share

Authors

JLJacob M. LevensteinCTCiara TreacySASophie C. Andrews

Discussion

Loading...

Member takes

Overview

Investigation reveals relationships between neurochemical concentrations and dementia risk in cognitively healthy older adults, suggesting new prevention strategies.

Key Points

  • Lower GABA+ levels correlate with higher dementia risk scores, indicating potential neurophysiological changes.
  • In the prefrontal cortex, reduced tNAA and tCho concentrations significantly predict increased dementia risk scores.
  • Magnetic resonance imaging and spectroscopy were used to analyze neurochemical changes in older adults' brains.
  • These findings may identify biomarkers for early dementia risk and guide new preventive treatment avenues.

Cite This Study

Levenstein et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d6477151ahttps://doi.org/10.1093/cercor/bhaf179
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70-year-olds2025
  2. 2Let’s Talk About Potentially Modifiable Risk Factors for Dementia2025
  3. 3Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function2025 · 46 citations
  4. 4Predicting cognitive decline in Alzheimer's disease: A real-life proof-of-principle study on multimodal assessment2025 · 1 citations
  5. 5Determinants of Cognitive and Brain Resilience to Reduced Neuronal Metabolism in Alzheimer’s Disease: A Longitudinal Whole-Brain MRSI Study2025