Impact of Concomitant Corticosteroid Use on Adverse Events in Ulcerative Colitis Clinical Trials

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Post-hoc analysis shows corticosteroid use increases adverse events in ulcerative colitis patients, suggesting monitoring needs.

Corticosteroid use is associated with higher rates of adverse events in ulcerative colitis trials, particularly infections and liver issues.
Among 2339 patients, 75.2% of corticosteroid users experienced adverse events by one year compared to 67.6% of non-users (p < 0.001).
The study utilized patient-level data from several placebo-controlled trials to assess the impacts of corticosteroid usage on adverse events.
Corticosteroid tapering strategies might help reduce the burden of adverse events during treatment.

Hamam et al. (2025) studied this question.

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