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August 25, 2025AntioxidantsOpen Access

Hyssopus cuspidatus Boriss Volatile Extract (SXC): A Dual-Action Antioxidant and Antifungal Agent Targeting Candida albicans Pathogenicity and Vulvovaginal Candidiasis via Host Oxidative Stress Modulation and Fungal Metabolic Reprogramming

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Authors

YGYun-Dan GuoMZMingxuan ZhangQYQ Yu

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Overview

Observational analysis revealed SXC alleviates vulvovaginal candidiasis symptoms and fungal growth in murine models, indicating its potential as a natural antifungal agent.

Key Points

  • SXC significantly reduced vaginal fungal burden and preserved epithelial integrity, demonstrating its potential in treating fungal infections.
  • Minimum inhibitory concentrations of SXC ranged from 0.125–16 μL/mL against bacterial and fungal pathogens, showing broad-spectrum activity.
  • Combining SXC with amphotericin B led to sustained bactericidal effects, highlighting potential for enhanced antifungal therapies.
  • Mechanistic studies indicated SXC modulated host immune responses by reducing oxidative stress via TLR4/NF-κB/NLRP3 pathway inhibition.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68af7f397567bf4f94ff5e87https://doi.org/10.3390/antiox14091046
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic Potential of Clove Syzygium aromaticum in Managing Vaginal Candidiasis Caused by Candida albicans among the Odisha Population2025
  2. 2Evaluation of the Antifungal Efficacy of Microbial Chondroitin Sulfate Against Candida Species in an Experimental Rat Model of Vulvovaginal Candidiasis2025
  3. 3Antifungal Potential of Sophora flavescens Root Extract: HR-LCMS Analysis and Molecular Docking of Bioactive Compounds Against Nosocomial Fungal Pathogens2025 · 3 citations
  4. 4Protective Effects of Cell-Free Supernatants from a Kefir-Derived Microbial Consortium against Multidrug-Resistant <i>Candida glabrata</i> Associated with Vulvovaginal Candidiasis2026
  5. 5Lactobacillus salivarius HHuMin-U attenuates vulvovaginal candidiasis via vaginal epithelial immune enhancement mediated by NF-κB activation2025