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October 23, 2025Open Access

Evaluation of the Antifungal Efficacy of Microbial Chondroitin Sulfate Against Candida Species in an Experimental Rat Model of Vulvovaginal Candidiasis

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Authors

RMRauf MelekoğluAEAyşe Şebnem ErenlerMHMustafa Hüz

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Overview

Experimental study shows chondroitin sulfate reduces fungal burden in vulvovaginal candidiasis, indicating immunomodulatory potential.

Key Points

  • Chondroitin sulfate reduced the vaginal fungal burden dose-dependently, with effects comparable to nystatin.
  • The 1% chondroitin sulfate treatment effectively lowered IL-17 levels in vaginal lavage fluid and improved histopathology scores in rats.
  • Assessment included cytokine levels, oxidative stress markers, and histopathological examinations to evaluate treatment effects.
  • Results may support the use of nonanimal-derived antifungal agents while highlighting the need for clinical trials.

Cite This Study

Melekoğlu et al. (2025) studied this question.

synapsesocial.com/papers/68f9840c1881b68f3b7ae7cbhttps://doi.org/10.21203/rs.3.rs-7613640/v1
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