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August 26, 2025CureusOpen Access

Stem Cell Therapy for Myocardial Infarction and Heart Failure: A Comprehensive Systematic Review and Critical Analysis

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Authors

MAMohamed R AbouzidAUAhmed Muaaz UmerSJSuman Kumar Jha

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Overview

Systematic review highlights enhancements in left ventricular ejection fraction from cell-based therapies for heart failure, suggesting significant potential for innovative treatments.

Key Points

  • Cell-based therapies improve cardiac repair outcomes, notably enhancing left ventricular ejection fraction.
  • Among 35 studies, significant advancements in heart function were observed through various cell types.
  • The review emphasizes angiogenesis as a key mechanism, challenging traditional treatment methods.
  • Despite optimistic results, issues with engraftment rates and cell differentiation warrant further research.

Cite This Study

Abouzid et al. (2025) studied this question.

synapsesocial.com/papers/68af7dfe7567bf4f94ff5536https://doi.org/10.7759/cureus.c259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stem cell therapy for cardiovascular diseases: Mechanisms, challenges, and therapeutic prospects2025
  2. 2Stem cell-based therapeutic approaches for heart failure2025
  3. 3Emerging advances in gene and cell therapy for heart failure: a systematic review2026
  4. 4Cardiac Repair and Mesenchymal Stem Cells: Exploring New Frontiers in Regenerative Medicine2025 · 3 citations
  5. 5Regenerative strategies for myocardial infarction: Integrating cell therapy and scaffold design2025