Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 26, 2025Discover Chemistry.Open Access

Synergistic action of phytoconstituents drives the anthelmintic potential of Croton penduliflorus stem bark extracts

View Full Paper
Ask AI
Bookmark
Share

Authors

KOKwadwo OwusuSOSelina Achiaa OwusuJMJehoshaphat Oppong Mensah

Discussion

Loading...

Member takes

Overview

This study investigates synergistic anthelmintic effects of Croton penduliflorus extracts against Eudrilus eugeniae, indicating new therapeutic prospects.

Key Points

  • The stem bark extract demonstrates strong anthelmintic activity, leading to paralysis in Eudrilus eugeniae within 8 minutes.
  • Soxhlet extraction yielded 3.06% from the bark, with dominant sterols identified through phytochemical screening.
  • Molecular docking indicates moderate affinity to β-tubulin, suggesting a multifactorial action mechanism.
  • GC–MS profiling revealed key bioactive phytoconstituents disrupting neuromuscular function.

Cite This Study

Owusu et al. (2025) studied this question.

synapsesocial.com/papers/68af7df87567bf4f94ff520ahttps://doi.org/10.1007/s44371-025-00265-1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vitro anthelmintic effect of aqueous extract of Croton blanchetiana leaf on sheep endoparasites2025
  2. 2Integrated In Vitro and In Silico Evaluation of the Antimicrobial and Cytotoxic Potential of Calotropis procera Leaf Ethanolic Extract: From GC-MS Profiling to Molecular Docking and Dynamics2025
  3. 3Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination2025
  4. 4Neuromuscular System of Nematodes Is a Target of Synergistic Pharmacological Effects of Carvacrol and Geraniol2025
  5. 5In vivo anthelmintic effects of polyphenol-rich extracts from the salt-tolerant species Cladium mariscus (L.) Pohl, 1809 and Limoniastrum monopetalum (L.) Boiss., 1848 against gastrointestinal parasitic nematodes in lambs2025