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September 10, 2025AnimalsOpen Access

Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination

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Authors

MMMaría Victoria MiróPIPaula IchinoseMLMercedes Lloberas

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Overview

Assessment of pharmacokinetic interactions in sheep using doramectin and phytochemicals, indicating enhanced antiparasitic efficacy.

Key Points

  • Combination therapy of doramectin with phytochemicals increases efficacy against Haemonchus contortus.
  • Higher effectiveness observed with the doramectin and cinnamaldehyde–pink grapefruit combination.
  • Ex vivo analysis showed reduced efflux of rhodamine 123 but no detectable pharmacokinetic interactions in vivo.
  • Suggests need for formulations ensuring sustained in vivo interaction between phytochemicals and drugs.

Cite This Study

Miró et al. (2025) studied this question.

synapsesocial.com/papers/68c243acb210217d647a878dhttps://doi.org/10.3390/ani15172539
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