August 1, 2025eJHaemOpen Access

Dual Assessment of the RBC Fraction Abnormally Retaining Mitochondria and of the RBC Mitochondrial Load Provides a New Clinical Parameter for Sickle Cell Disease Patients

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This assessment evaluates mitochondrial retention and load in red blood cells, suggesting implications for sickle cell disease therapies.

This assessment offers a novel approach to evaluate mitochondrial retention in red blood cells, indicating its role in sickle cell disease.
The number of mitochondria in red blood cells was quantified at 21 copies per total RBC, with 11% of RBCs retaining mitochondria.
Methodology employed includes qPCR for mitochondrial DNA quantification from sorted red blood cells in pediatric sickle cell patients.
These findings highlight potential therapeutic pathways to address mitophagy defects in managing sickle cell disease.

Soupène et al. (2025) studied this question.

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