Exploring Dysregulated Plasma Metabolites in Sickle‐Cell Disease Patients Using Comparative NMR‐Based Metabolomics

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Discussion

Comparative study reveals significant metabolite differences in sickle-cell disease patients, suggesting underlying pathophysiology.

Significant differences in metabolite concentrations were found between healthy controls and SCD patients.
The study identified 11 out of 29 metabolites linked to glycolysis, hypoxic, and acute-stress conditions.
A small cohort of 26 SCD patients from eastern India was analyzed using NMR-based metabolomics.
The findings highlight regional variations in SCD pathophysiology, influencing potential therapeutic strategies.

Pradhan et al. (2025) studied this question.

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