August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Increase of the Ampa-Evoked Response in Prefrontal Cortex Pyramidal Neurons Following Acute Administration of Ketamine and S-Ketamine in Rats

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Increased responsiveness to AMPA was observed 30 minutes after ketamine administration, indicating enhanced neuronal activity.
Glutamate pyramidal neurons showed no change in responsiveness to NMDA, highlighting ketamine's specific impact on AMPA receptors.
Extracellular recordings were conducted in the medial prefrontal cortex of Sprague Dawley rats to assess neuronal response to ketamine.
Findings suggest that AMPA-induced response increases may underlie the antidepressant effects of ketamine and s-ketamine.

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Implication

Electrophysiological analysis demonstrates increased AMPA responsiveness in pyramidal neurons after ketamine infusion, indicating its role in enhancing glutamatergic transmission.

Cite This Study

Blier et al. (2025) studied this question.

synapsesocial.com/papers/68af2ee5cf1dd9ea359e67da https://doi.org/10.1093/ijnp/pyaf052.304

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Implication

Electrophysiological analysis demonstrates increased AMPA responsiveness in pyramidal neurons after ketamine infusion, indicating its role in enhancing glutamatergic transmission.

Increase of the Ampa-Evoked Response in Prefrontal Cortex Pyramidal Neurons Following Acute Administration of Ketamine and S-Ketamine in Rats

Key Points

Discussion

Implication

Cite This Study

Increase of the Ampa-Evoked Response in Prefrontal Cortex Pyramidal Neurons Following Acute Administration of Ketamine and S-Ketamine in Rats

Key Points

Discussion

Implication

Cite This Study

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