August 25, 2025BMC GastroenterologyOpen Access

Investigating the relationship between Helicobacter pylori and intestinal Clostridioides difficile infection: evidence from a cross-sectional study

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Discussion

Cross-sectional study reveals H. pylori infection links to increased CDI risk, suggesting gut microbiota shifts.

Clostridioides difficile infection prevalence was significantly higher in H. pylori-positive patients at 13.7%.
Logistic regression analysis indicated a strong association (OR: 1.817) of H. pylori infection with CDI risk.
This retrospective study used a sample of 1,624 hospitalized patients undergoing both H. pylori and CDI testing.
Findings suggest that H. pylori infection may play a role in the risk of developing CDI following alterations in gut microbiota.

Yin et al. (2025) studied this question.

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