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August 25, 2025Open Access

Genetic insights into the causal role of metabolic, immune, and microbial factors in migraine

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Authors

ZXZixuan XingJGJunxiang GuCWCong Wu

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Overview

This genetic epidemiology analysis identifies causal relationships in migraine, suggesting new therapeutic targets and biomarkers.

Key Points

  • The study found 95 potential causal factors for migraine, including key metabolites and immune profiles.
  • Analysis revealed specific risk factors like alpha-ketoglutarate to ornithine ratio linked to migraine risk.
  • Utilizing a two-sample Mendelian randomization approach, it investigated the role of metabolites and immune responses.
  • Findings suggest independent pathways influence migraine risk, highlighting possibilities for new treatments.

Cite This Study

Xing et al. (2025) studied this question.

synapsesocial.com/papers/68af7b187567bf4f94ff293chttps://doi.org/10.21203/rs.3.rs-7372193/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis2025 · 1 citations
  2. 2Circulating Cytokines Mediate the Causal Relationship between Plasma Lipids and Migraine and its Subtypes: A Mediated Mendelian Randomization Study2025
  3. 3Gut microbiota, probiotics, and migraine: a clinical review and meta-analysis2025
  4. 4Cellular and molecular characterisation of the peripheral immune environment in migraine2025
  5. 5Epigenome-wide DNA methylation profiling reveals risk genes for migraine and its subtypes2025