August 24, 2025mLifeOpen Access

The global genomic landscape of hypervirulent Klebsiella pneumoniae from 1932 to 2021

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Discussion

Genomic epidemiology highlights specific clonal groups and antimicrobial resistance in hypervirulent Klebsiella pneumoniae isolates.

Genomic analysis reveals that 41.58% of isolates are multidrug-resistant, raising public health concerns.
Six dominant clonal groups including CG23 and CG258 were identified among global hvKp isolates.
Analysis of 2097 hvKp isolates used advanced sequencing technologies, including Illumina and PacBio platforms.
Findings emphasize the genetic basis of hvKp dissemination, highlighting urgent prevention needs.

Jiang et al. (2025) studied this question.

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