September 10, 2025iMetaOpen Access

Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent Klebsiella pneumoniae

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Genomic analysis reveals trade-offs between virulence and carbapenem resistance in hypervirulent strains, indicating regional influences.

Hypervirulent strains of klebsiella pneumoniae show notable trade-offs between virulence and resistance.
Antimicrobial resistance patterns correlate with regional usage of carbapenems, particularly in Europe and Asia.
Isolates with specific resistance genes demonstrate significant changes in their virulence determinants.
Core genomic regions in resistant isolates exhibit higher mutation rates impacting virulence pathways.

Wu et al. (2025) studied this question.

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