August 25, 2025Frontiers in GeneticsOpen Access

Comparative analysis of sex-dependent serum metabolomic patterns across the lifespan of rhesus macaques

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Pronounced sex differences in metabolomic aging trajectories were observed, particularly in lipid and amino acid metabolism.
Females showed a significant increase in serum triglycerides and amino acids, while males displayed varied lipid profiles without changes in triglycerides.
Targeted serum metabolomics were performed on 58 rhesus macaques aged 1.66 to 25.71 years to assess metabolic patterns.
These findings support the inclusion of sex as a critical variable in aging research to identify biomarkers.

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Targeted serum metabolomics reveal age-related metabolic changes between sexes in rhesus macaques, highlighting biological variability.

Metzler et al. (2025) studied this question.

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