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August 24, 2025Journal of Pure & Applied SciencesOpen Access

Evaluation and Comparison of Two Spectrophotometric Approaches for Tramadol Hydrochloride Quantification in Pharmaceutical Products

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Authors

RERabia EshkourfuAAAmina AmimnEAElham Alterhoni

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Overview

This evaluation compares two spectrophotometric methods for tramadol hydrochloride analysis, suggesting both are valid for pharmaceutical use.

Key Points

  • Method A achieved a linear range of 30–150 μg/mL, showing a reliable R² value of 0.9993, while Method B followed closely with a range of 10–50 μg/mL at R² = 0.9997.
  • Both methods underwent validation against ICH guidelines, demonstrating a relative standard deviation (RSD) of less than 2%, confirming their precision and accuracy.
  • The evaluation highlights that both spectrophotometric methods offer a reliable, simple, and cost-effective approach to quantify tramadol hydrochloride in pharmaceuticals.
  • Final results suggest that both methods are environmentally friendly and suitable for quality control in pharmaceutical formulations.

Cite This Study

Eshkourfu et al. (2025) studied this question.

synapsesocial.com/papers/68af799f7567bf4f94ff117ehttps://doi.org/10.51984/jopas.v24i3.4012
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