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August 23, 2025Journal of Biomechanical EngineeringOpen Access

Integrating imaging and invasive pressure data into a multi-scale whole-heart model

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Authors

MSMarina StrocchiCAChristoph M. AugustinMGMatthias A. F. Gsell

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Overview

Systematic method integrates clinical data and pressure data into a whole-heart model, suggesting improved treatment decisions.

Key Points

  • The model showed strong alignment with clinical targets, achieving fitting within 0.8–10.8% of mean values and 1.4 standard deviations from targets.
  • Calibration involved 25 parameters to match various key pressures and volumes, including left ventricle and atrial metrics.
  • Using ECG-gated CT and invasive pressure data, the model effectively simulated heart motion and haemodynamic response.
  • This method enhances the potential for personalized treatment in cardiovascular diseases, emphasizing clinical decision-making.

Cite This Study

Strocchi et al. (2025) studied this question.

synapsesocial.com/papers/68af782c7567bf4f94ff0b99https://doi.org/10.1115/1.4069497
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