August 21, 2025

Three months of weekly rifapentine and isoniazid versus four months of rifampicin for tuberculosis infection: a randomised controlled trial

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Discussion

Randomised trial shows higher treatment completion for rifapentine and isoniazid in tuberculosis infection, indicating improved adherence.

Treatment completion was significantly higher in the rifapentine and isoniazid group at 84.9%, compared to 65.4% for rifampicin.
The study involved 210 participants randomly assigned to either regimen, with the 3HP group receiving weekly SMS reminders.
Analyzed results followed the intention-to-treat principle, encompassing all randomized participants, ensuring robustness.
Findings support implementing the 3HP regimen more widely in tuberculosis infection management to enhance patient outcomes.

Chang et al. (2025) studied this question.

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Randomised trial shows higher treatment completion for rifapentine and isoniazid in tuberculosis infection, indicating improved adherence.