September 11, 2025Jornal Brasileiro de PneumologiaOpen Access

Treatment completion and challenges in rolling out 12-dose weekly rifapentine plus isoniazid to prevent tuberculosis among people living with HIV and pediatric household contacts in Brazil

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Treatment completion rates were notably high at 83.7% for PLHIV and 82.4% for household contacts.
Adverse event-related discontinuation was low, with only 2.4% of PLHIV discontinuing treatment due to side effects.
The study observed a successful rollout of the 3HP regimen across two Brazilian cities, enhancing access to tuberculosis preventive therapy.
Overall, 99.6% of PLHIV remained free of tuberculosis after six months of follow-up.

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Implication

Multicenter project shows high completion rates for preventive tuberculosis therapy in people living with HIV, suggesting effective implementation strategies.

Cite This Study

Salles et al. (2025) studied this question.

synapsesocial.com/papers/68d41711713b0b5dfea62ace https://doi.org/10.36416/1806-3756/e20250125

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Implication

Multicenter project shows high completion rates for preventive tuberculosis therapy in people living with HIV, suggesting effective implementation strategies.

Treatment completion and challenges in rolling out 12-dose weekly rifapentine plus isoniazid to prevent tuberculosis among people living with HIV and pediatric household contacts in Brazil

Key Points

Discussion

Implication

Cite This Study

Treatment completion and challenges in rolling out 12-dose weekly rifapentine plus isoniazid to prevent tuberculosis among people living with HIV and pediatric household contacts in Brazil

Key Points

Discussion

Implication

Cite This Study