August 20, 2025Journal of Cerebral Blood Flow & Metabolism

Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke

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Authors

YMYoshifumi MiyauchiJichi Medical University NMNobukazu MiyamotoJuntendo University TIToshiki InabaJuntendo University

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Implication

Observational analysis shows improved recovery in ischemic stroke after treatment with exercise-derived extracellular vesicles, indicating potential for novel therapies.

Key Points

Exercise-derived extracellular vesicles enhance recovery after ischemic stroke, reducing neuronal apoptosis and improving motor function.
In exercise-trained rats, aPRP-EVs significantly improved neuronal viability and TGF-β signaling after oxygen-glucose deprivation.
Administration of platelet-rich plasma-derived extracellular vesicles was tested in adult male Wistar/ST rats after permanent middle cerebral artery occlusion.
These findings suggest that exercise-derived PRP-EVs may facilitate neuroregeneration and support chronic stroke recovery.

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Miyauchi et al. (2025) studied this question.

synapsesocial.com/papers/68af751a7567bf4f94fee2ec https://doi.org/10.1177/0271678x251369219

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Implication

Observational analysis shows improved recovery in ischemic stroke after treatment with exercise-derived extracellular vesicles, indicating potential for novel therapies.

Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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