August 3, 2025Open Access

Exercise-induced plasma-derived extracellular vesicles increase adult hippocampal neurogenesis

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Authors

MCMeghan G. ConnollyUniversity of Alberta AFAlexander M. FlifletUniversity of Illinois Urbana-Champaign PRPrithika RaviUniversity of Illinois Urbana-Champaign

Discussion

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Implication

Experimental evidence shows plasma-derived extracellular vesicles enhance neurogenesis and astrogliogenesis in sedentary mice, implying therapeutic potential for neurological disorders.

Key Points

Exercise increases neurogenesis in the hippocampus, a region crucial for memory and learning.
Plasma-derived extracellular vesicles from exercising mice significantly elevated brain cell production in sedentary mice.
The study involved plasma extraction and EV injection in sedentary mice across two independent cohorts for reliability.
Findings suggest exercise-derived EVs could serve as a therapy for conditions linked to hippocampal damage.

Cite This Study

Connolly et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d0641 https://doi.org/10.1101/2025.08.02.668291

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Implication

Experimental evidence shows plasma-derived extracellular vesicles enhance neurogenesis and astrogliogenesis in sedentary mice, implying therapeutic potential for neurological disorders.