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August 20, 2025AJP Heart and Circulatory PhysiologyOpen Access

5-Hydroxytryptamine may be a viable treatment option for hypertension resistant to diuretic treatment

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Authors

RKRachel KramHGHannah GarverGFGregory D. Fink

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Overview

Chronic infusion of 5-HT reduces mean arterial pressure in male Dahl-SS rats, suggesting potential for combined therapy.

Key Points

  • 5-hydroxytryptamine significantly lowers mean arterial pressure in rats resistant to diuretics, demonstrating promising antihypertensive effects.
  • Rats on a 4% NaCl diet exhibited a reduction in mean arterial pressure by 20.7 mmHg with combined 5-HT and trichlormethiazide treatment.
  • Assessment included chronic infusion using radiotelemeters to monitor blood pressure changes over a week period.
  • These results highlight the potential of 5-HT to complement standard hypertension treatments even in resistant cases.

Cite This Study

Kram et al. (2025) studied this question.

synapsesocial.com/papers/68af75147567bf4f94fee179https://doi.org/10.1152/ajpheart.00520.2025
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  1. 1Time-Restricted Feeding Attenuates Salt-Sensitive Hypertension and Renal Damage2025
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  4. 4Blood Pressure Responses to Dietary Salt in Renin-Deficient Dahl Salt-Sensitive Rats2026
  5. 5Comparison of the Efficacy of Different Treatment Regimens for Resistant Hypertension: A Systematic Review and Network Meta‐Analysis2026