From CK-MB to MicroRNAs: Evolving Biomarker Strategies for Early Diagnosis of Myocardial Infarction

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Discussion

Systematic review evaluates biomarkers and microRNAs for enhanced specificity and sensitivity in myocardial infarction.

High-sensitivity cardiac troponins showed sensitivities nearing 90%, enhancing early diagnosis of myocardial infarction.
Traditional biomarkers like CK and CK-MB achieved specificity up to 96%, although they had limited sensitivity overall.
Emerging microRNAs such as miR-499 and miR-133a demonstrated pooled sensitivities and specificities around 0.88, indicating their promise.
Combining high-sensitivity troponins with molecular markers and advanced models may improve diagnostic precision and decision-making.

Deepak et al. (2025) studied this question.

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