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August 21, 2025World Journal of Cardiology

Relationship between genotype and clinical phenotype of hypertrophic cardiomyopathy

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Authors

LZLanlan ZhangBWBo WangJWJing Wang

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Overview

Analysis of genotype-phenotype associations in hypertrophic cardiomyopathy patients, highlighting genetic factors and clinical outcomes.

Key Points

  • Hypertrophic cardiomyopathy (HCM) shows a prevalence of 1:500 to 1:200, indicating a significant public health concern.
  • 60%-70% of HCM cases show familial clustering, underscoring the genetic nature of this cardiovascular disease.
  • The assessment focuses on the diagnostic criteria and pathological manifestations related to diverse genotypes.
  • This information may lead to improved diagnostic and therapeutic strategies for HCM patients.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af6d847567bf4f94fea7a1https://doi.org/10.4330/wjc.v17.i8.107847
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic, Clinical, and Sociodemographic Profile of Individuals with Diagnosis or Family History of Hypertrophic Cardiomyopathy: Insights from a Prospective Cohort2025 · 2 citations
  2. 2Genotype-Phenotype Relationship in Hypertrophic Cardiomyopathy2025 · 3 citations
  3. 3Hypertrophic Cardiomyopathy: Current Perspectives2025
  4. 4Genetic insights into hypertrophic cardiomyopathy: pathogenesis, diagnosis, and therapeutic implications2025 · 9 citations
  5. 5Network Analysis and Structural Equation Modelling of Genetic and Environmental Factors in Hypertrophic Cardiomyopathy Progression2025