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August 21, 2025Frontiers in Cell and Developmental BiologyOpen Access

Genome-wide DNA methylation analysis identifies kidney epigenetic dysregulation in a cystinosis mouse model

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Authors

MRMarcelo RossiACAndrea CiolfiVMValentina Matteo

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Overview

Genome-wide analysis reveals epigenetic dysregulation in cystinosis, suggesting methylation impacts kidney function.

Key Points

  • Hypermethylation in cystinotic kidneys indicates significant epigenetic dysregulation contributing to kidney damage.
  • Differentially methylated CpG sites predominantly affect genes crucial for kidney function and proximal tubule physiology.
  • Genome-wide dna methylation analysis compared wild type and cystinosis mouse models to identify critical changes.
  • Results suggest potential therapeutic avenues using epigenetic modulation in treating cystinosis-related renal dysfunction.

Cite This Study

Rossi et al. (2025) studied this question.

synapsesocial.com/papers/68af40a1cf1dd9ea359ecb3dhttps://doi.org/10.3389/fcell.2025.1638123
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Also Consider

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  1. 1The Impact of Epigenomics on Understanding Kidney Diseases2025
  2. 2DNA methylation in chronic kidney disease2025 · 8 citations
  3. 3Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes2026 · 4 citations
  4. 4Novel approaches and applications in identifying DNA methylation markers of cardio-kidney-metabolic disease.2025
  5. 5Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal disease2025