August 21, 2025Journal of NanobiotechnologyOpen Access

Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment

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Authors

GLGuoyu LiShihezi University HCHongyu Chen WCWenwen ChenNanjing Normal University

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Implication

Self-assembled peptide dendron C8-2 demonstrates superior antifungal effects on Candida albicans in fungal keratitis, highlighting a promising new treatment approach.

Key Points

C8-2 effectively eliminates Candida albicans in fungal keratitis models, enhancing treatment outcomes.
Exhibiting significant antifungal potency, C8-2 exhibits favorable biocompatibility and robust stability.
Innovative peptide dendron design employs fatty acids, addressing the challenge of drug-resistant fungi.
Mechanistic studies show C8-2 disrupts cell membranes, increasing permeability and inducing cell content release.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af409acf1dd9ea359ec977 https://doi.org/10.1186/s12951-025-03670-x

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Implication

Self-assembled peptide dendron C8-2 demonstrates superior antifungal effects on Candida albicans in fungal keratitis, highlighting a promising new treatment approach.

Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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