December 4, 2025ACS Nano

Membrane-Targeting Poly(Amino Acids) with a Phage-Like Action Process for Antifungal Therapy

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Guanidine-functionalized poly(amino acid) reduces fungal burden in murine models, suggesting potential for broader antifungal therapy.

PArg20 significantly reduces fungal eradication time from over 2 h to just 10 min and shows no resistance after 15 passages.
This approach emphasizes membrane-targeting and a phage-like action against invasive fungal infections.
The antifungal strategy markedly improves treatment outcomes while addressing issues of drug resistance.
The use of guanidine-functionalized poly(amino acid) demonstrates high biocompatibility and lowers inflammation in the treatment process.

Zhao et al. (2025) studied this question.

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