Visible-Light-Promoted Tandem Radical Fluoroalkylation/ Cyclization to Access Fluoroalkyl-Containing Chromones/Chroman-4-ones

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The reaction produces 3-fluoroalkyl-substituted chromone derivatives and chroman-4-ones efficiently, impacting synthetic chemistry.
Key metrics include successful transformation of o-hydroxyaryl enaminones with CF3Br and dibromotetrafluoroethane.
This includes a visible-light-induced method incorporating fac-IrIII(ppy)3 as a catalyst under mild conditions.
The findings highlight a novel approach for creating fluoroalkyl compounds, expanding synthetic accessibility.

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Tandem radical fluoroalkylation and cyclization creates fluoroalkyl chromones in efficient reaction of enaminones, suggesting new synthetic pathways.

Ren et al. (2025) studied this question.

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Tandem radical fluoroalkylation and cyclization creates fluoroalkyl chromones in efficient reaction of enaminones, suggesting new synthetic pathways.