Multicomponent reaction constructs 3-fluoroalkyl-substituted indoles, suggesting efficient synthesis methods.
A visible-light-induced multicomponent tandem cyclization of o-alkenyl aromatic isocyanides with fluorinated alcohols and sulfur ylides as carbon radical precursors was developed for the first time. This reaction provides an efficient method for the construction of 3-fluoroalkyl-substituted indoles from readily available acyclic starting materials with the formation of two C–O bonds and two C–C bonds in a single step. Further applications, including synthesis of 2-(1H-indol-2-yl)-1,4-diphenylbutane-1,4-diol,2-(thiophen-3-yl/1H-pyrrol-3-yl)-1H-indoles and 9H-carbazole, demonstrated the tremendous potential of the multicomponent reaction.
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Gong et al. (2025) studied this question.