August 20, 2025Scientific ReportsOpen Access

Decoding mechanosensitive genes in cardiac fibroblasts via 3D hydrogel models of fibrosis

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Upregulation of a 98-gene cluster linked to cardiac fibrosis was observed across stiffness gradients.
Key genes like THBS2 and DCN were confirmed to play crucial roles in fibroblast activation through functional assays.
Using a 3D hydrogel model, the study reveals the molecular response mechanisms of fibroblasts under varying stiffness.
Findings underscore potential diagnostic markers for cardiac conditions, particularly in dilated and hypertrophic cardiomyopathy.

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RNA sequencing identified mechanosensitive genes in cardiac fibroblasts, suggesting new therapeutic targets for fibrosis.

Chen et al. (2025) studied this question.

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