October 12, 2025AJP Heart and Circulatory PhysiologyOpen Access

3D Biomechanics and Epigenomics Reveal Atypical Fibroblast Responses in Cardiometabolic Disease

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3D bioprinted platforms show reduced fibroblast proliferation and relevant transcriptional responses to biomechanical stress.
Chromatin accessibility profiling indicates a unique gene program in fibroblasts exposed to excess fatty acids in 2D vs. 3D settings.
Inclusion of iPSC-derived cardiac fibroblasts demonstrated sex-dependent differences in fibrotic gene induction, highlighting biological relevance.
This research underscores the limitations of 2D systems while promoting 3D technologies for studying complex cardiometabolic conditions.

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Implication

Observational analysis reveals atypical fibroblast responses and gene regulation in 3D cultures, suggesting significant insights for cardiometabolic research.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdaf46 https://doi.org/10.1152/ajpheart.00602.2025

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Implication

Observational analysis reveals atypical fibroblast responses and gene regulation in 3D cultures, suggesting significant insights for cardiometabolic research.

3D Biomechanics and Epigenomics Reveal Atypical Fibroblast Responses in Cardiometabolic Disease

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Implication

Cite This Study

3D Biomechanics and Epigenomics Reveal Atypical Fibroblast Responses in Cardiometabolic Disease

Key Points

Discussion

Implication

Cite This Study

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