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August 20, 2025Phytotherapy Research

The SLCO4A1‐Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway

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Authors

DXDayan XiongLMLin MiaoWXWeixi Xie

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Overview

Animal model shows lysionotin improves antioxidant function and reduces oxidative stress in acute lung injury, indicating potential clinical applications.

Key Points

  • Lysionotin significantly reduces oxidative stress and inflammation in acute lung injury models, preserving endothelial function and integrity.
  • Key evidence highlights that lysionotin activates the AMPK/Nrf2 pathway, enhancing antioxidant capacity and protecting endothelial cells from damage.
  • Observational analysis in murine models shows that lysionotin's effects are dependent on the SLCO4A1 channel, crucial for AMPK activation.
  • This research supports exploring lysionotin as a potential therapeutic agent in treating acute lung injury and related conditions.

Cite This Study

Xiong et al. (2025) studied this question.

synapsesocial.com/papers/68af4088cf1dd9ea359ebf2dhttps://doi.org/10.1002/ptr.70024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lysionotin attenuates bleomycin-induced pulmonary fibrosis by activating AMPK/Nrf2 pathway2025
  2. 2Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response2025 · 4 citations
  3. 3Lycium ruthenicum Murr. Polysaccharide Attenuated Inflammatory Response and Intestinal Flora Dysbiosis in LPS-Induced Acute Lung Injury in Mice2025
  4. 47-Methoxyflavanone Alleviates LPS-Induced Acute Lung Injury by Suppressing TLR4/NF-κB p65 and ROS/Txnip/NLRP3 Signaling2025
  5. 5Onion-Mitochondria Inhibit Lipopolysaccharide-Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function.2025 · 4 citations