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August 17, 2025ACS OmegaOpen Access

Long-Term In Situ Treatment of Arthritis with Injectable Biocompatible Organogel Activation

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Authors

CDChengbiao DingXFXiao-Jun FengLMLinqiang Mei

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Overview

This hydrogel system suppresses inflammation in rheumatoid arthritis, suggesting improved joint repair and drug delivery.

Key Points

  • Local injection of activated hydrogel reduces bone destruction and inhibits pannus formation effectively.
  • In vivo studies have shown significant suppression of inflammatory factors including IL-6 and TNF-α.
  • The injectable system enhances the safety and absorption of quercetin compared to its unactivated form.
  • This treatment highlights the potential of responsive drug delivery systems in managing autoimmune conditions.

Cite This Study

Ding et al. (2025) studied this question.

synapsesocial.com/papers/68af3e3ccf1dd9ea359eb06fhttps://doi.org/10.1021/acsomega.5c02934
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Also Consider

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  1. 1Advances in Intra-Articular Injection Hydrogel Drug Delivery Systems in the Treatment of Rheumatoid Arthritis2025 · 19 citations
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  5. 5Injectable Thermosensitive Hydrogel Encapsulating Mesenchymal Stem Cell Membrane-Based Biomimetic Liposomes for Local Rheumatoid Arthritis Treatment2025 · 2 citations