August 1, 2025

Glibenclamide in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

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Discussion

Systematic review assesses glibenclamide's impact on outcomes in aSAH patients, revealing no significant differences in key metrics.

No significant improvements in outcomes for aSAH patients treated with glibenclamide, compared to controls.
Meta-analysis of four RCTs found no differences in delayed cerebral ischemia or death rates among groups.
Conducted in accordance with PRISMA guidelines, utilizing statistical analysis with RevMan software.
Findings highlight the need for caution regarding interpretation due to potential publication bias.

Alsubaiei et al. (2025) studied this question.

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