July 28, 2025Medical Principles and PracticeOpen Access

Efficacy and Safety of Glibenclamide on Functional Outcomes and Cerebral Edema Following Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Glibenclamide showed no overall improvement in clinical outcomes for acute stroke patients.
Subgroup analysis indicated a benefit for intracerebral hemorrhage patients regarding modified Rankin Scale scores.
The meta-analysis included seven randomized controlled trials with a total of 1,225 patients.
Safety concerns arose with an increased risk of hypoglycemia associated with glibenclamide use.

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Implication

Systematic review demonstrates glibenclamide's limited effectiveness on stroke outcomes in 1,225 patients, suggesting safety considerations are necessary.

Cite This Study

Hegazi et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8ceb34 https://doi.org/10.1159/000547648

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Implication

Systematic review demonstrates glibenclamide's limited effectiveness on stroke outcomes in 1,225 patients, suggesting safety considerations are necessary.

Efficacy and Safety of Glibenclamide on Functional Outcomes and Cerebral Edema Following Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Key Points

Discussion

Implication

Cite This Study

Efficacy and Safety of Glibenclamide on Functional Outcomes and Cerebral Edema Following Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Key Points

Discussion

Implication

Cite This Study