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August 20, 2025Journal of Pharmacology and PharmacotherapeuticsOpen Access

Diabetes Mellitus-related Pathogeny: A Precipitating Factor for Alzheimer’s Disease—An Insight on Repurposing Diabetes Pharmacological Treatments in Alzheimer’s Disease

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Authors

COChiamaka OnyekwulujeNNNokwanda N. NgcoboNSNtethelelo Sibiya

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Overview

This review uncovers links between diabetes mellitus and Alzheimer's disease, suggesting drug repurposing may enhance treatment outcomes.

Key Points

  • Repurposing diabetes treatments shows promise for improving outcomes in Alzheimer's disease, highlighting metabolic dysfunction's role.
  • Key findings reveal metabolic dysfunction, insulin resistance, and inflammation as shared features of diabetes and Alzheimer's.
  • Literature analysis indicates potential of GLP-1 agonists, SGLT-2 inhibitors, and intranasal insulin in treating Alzheimer's.
  • Understanding the overlap between diabetes mellitus and Alzheimer's disease may enable novel therapeutic strategies for patients.

Cite This Study

Onyekwuluje et al. (2025) studied this question.

synapsesocial.com/papers/68af3e34cf1dd9ea359ead01https://doi.org/10.1177/0976500x251365078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy2025 · 8 citations
  2. 2GLP-1R as a potential link between diabetes and Alzheimer’s disease2025
  3. 3A systematic review on type 3 diabetes: bridging the gap between metabolic dysfunction and Alzheimer’s disease2025
  4. 4Neuroglial Crosstalk in Alzheimer's Disease and Diabetes Mellitus: Unravelling Shared Pathophysiological Pathways and Therapeutic Insights2025
  5. 5Exploring The Interconnected Pathways of Cognitive Decline and Type II Diabetes Mellitus: The Role of Glucose and Insulin Metabolism2025