Fractional flow reserve vs angiography to guide percutaneous coronary intervention: an individual patient data meta-analysis

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Meta-analysis shows FFR-guided PCI reduces major adverse cardiac events in chronic coronary syndrome patients, highlighting its clinical importance.

FFR-guided PCI resulted in a 2.6% lower rate of major adverse cardiac events compared to angiography after one year.
The analysis included data from five trials with a total of 2493 patients, demonstrating significant safety benefits.
Randomized controlled trials showed that fewer peri-procedural MIs occurred in the FFR group, underscoring its effectiveness.
The findings suggest that using FFR guidance may lower the incidence of complications in coronary interventions.

Mangiacapra et al. (2025) studied this question.

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View Full Paper

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Meta-analysis shows FFR-guided PCI reduces major adverse cardiac events in chronic coronary syndrome patients, highlighting its clinical importance.

FFR-guided PCI resulted in a 2.6% lower rate of major adverse cardiac events compared to angiography after one year.
The analysis included data from five trials with a total of 2493 patients, demonstrating significant safety benefits.
Randomized controlled trials showed that fewer peri-procedural MIs occurred in the FFR group, underscoring its effectiveness.
The findings suggest that using FFR guidance may lower the incidence of complications in coronary interventions.

Mangiacapra et al. (2025) studied this question.

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